LIMB SPARING IN DOGS – PERSONALIZED ENDOPROSTHESES AND CUTTING GUIDES
The first personalized surgical implant commercialized for veterinary surgery
Managing bone cancer in pets
Osteosarcoma accounts for approximately 85% of bone tumors in dogs and ~ 10,000 new diagnostics are made each year in the United States. The distal radius/ulna is the most common site of the primary tumor.
Limb sparing in combination with arthrodesis represents a common approach to treat this condition. During limb sparing surgery, the affected bone portion is removed en bloc and the bone defect is spanned. This new technology and approach contrast with existing limb sparing techniques associated with post-surgery complication rates around 75%, rendering limb imputation the only available surgical treatment. In addition of having very few complications, this innovative solution is characterized by a very limited period of convalescence, and a very good walking ability of the animal right after the operation.
The world’s first customized 3D-printed surgical implant for dogs
Issued from the collaboration between 3 top institutions in North America, 3D-printed endoprostheses (Fig. 1) and a custom cutting guide have been developed and commercialized for an efficient limb sparing at distal radius or proximal humerus. The patient-specific implant is contoured to an individual geometry to fit perfectly for a better withstanding of the loads transmitted through the limb. It allows the surgical time to be significantly decreased, thus reducing the infection rates. The 3D-printing also facilitates controlled surface texturing of endoprosthesis and the subsequent bioactivation using local delivery of chemotherapeutics. Coupled with the implant, the personalized cutting guide allows the osteotomy to be performed precisely at the location prescribed by the surgeon, providing an ideal interface between the implant and the remaining bone.
Development stage TRL9
A clinical trial at Colorado State University was successfully conducted on five dogs suffering from radius osteosarcoma.
The technology is now at a commercial stage. Since last year, several endoprostheses have been sold and implemented in commercial mode with a pool of veterinarians promoting the implants to their customers in US and Canada.
A patient specific implant for a safer surgery
-Guarantees adequate biomechanical functionality of the spared limb
-Lower risk of implant/bone failure
-Reduced surgical time
-Lower infection risk
-Reduced risk of tumor recurrence
-Improves patient’s quality of life
-Patent applications filed in US and Canada
-Looking for manufacturer/distributor partners
If you are interested by this technology, please contact :
Sébastien Chaffre, Director Business Development, Life Sciences
email@example.com, (438) 728-7580
-École de Technologie Supérieure
-Université de Montréal
-Colorado State University
Vladimir Brailovski, ing., PhD, Professor of Mechanical Engineering
Vladimir Brailovsky is Professor of Mechanical Engineering at ÉTS since 2000, where he was hired after spending 7 years at École Polytechnique de Montréal. He is also a researcher at the Centre de recherche de l’Hôpital du Sacré-Cœur de Montréal. Dr. Brailovsky holds an internationally recognized expertise in the design, manufacture and application of shape memory alloys. Much of his knowledge is in the border areas of mechanical engineering and materials science. Since 2015, he is primarily interested in the application of 3D printing technology in the medical and aerospace fields. He currently leads a research team of about twenty people working on multidisciplinary projects with several industrial opportunities.
Bernard Séguin, DMV, MSc Diplomate ACVS, Professor of veterinary surgical oncology
Dr. Bernard Séguin is a Professor of veterinary surgical oncology at the Flint Animal Cancer Center, Colorado State University. He is a diplomate of the American College of Veterinary Surgeons (ACVS) and an ACVS Founding Fellow in Surgical Oncology. His research interests include osteosarcoma in dogs with a focus on limb sparing surgery. He has developed several novel limb sparing techniques in dogs.
Bertrand Lussier, DMV, MSc Diplomate ACVS, Professor of surgery, Department of Clinical Sciences
Dr. Lussier graduated as a veterinarian in 1986 (University of Montreal), completed his surgical training in 1994 (Cornell university) and obtained his specialist’s certification by the ACVS in 1997. After a few years as a surgeon in private practice, he came back to academia at the University of Montreal in 1999 and became Professor of Surgery in 2012. As a veterinary surgeon, his surgical expertise is vast and his research interests include osteoarthritis (pain and function), the evaluation of the ruptured cranial cruciate ligament of the canine knee joint and the development and validation of personalized 3D printed endoprostheses for canine limb sparing. Dr Lussier has been honoured with 10 awards of excellence in teaching, clinical teaching and research.
Anatolie Timercan, PhD student, Mechanical Engineering
Anatolie Timercan is a PhD student at the Mechanical Engineering Department of École de Technologie Supérieure (ÉTS) in V. Brailovski’s Shape Memory Alloys and Intelligent Systems Laboratory (LAMSI). His doctoral thesis is focused on the design and additive manufacturing of cellular structures integrating shape memory alloys for use in biomedical applications. In 2018, he completed his Master`s studies at ÉTS with a mention of excellence for the design, additive manufacturing and validation of personalized endoprostheses for dogs afflicted by osteosarcoma. Since 2016, he has been a teaching auxiliary for various undergraduate and graduate courses at ÉTS.
Yvan Petit, B.Ing., M.Sc.A., Ph.D., Professor mechanical engineering
Séguin B, Pinard C, Lussier B, Williams D, Griffin L, Podell B, Mejia S, Timercan A, Petit Y, Brailovski V. 2020. Limb‐sparing in dogs using patient‐specific, three‐dimensional‐printed endoprosthesis for distal radial osteosarcoma: A pilot study. Veterinary and Comparative Oncology. 18: 92-104